SCIENCE ALERT Recognition by human gut ãä cells of stress inducible major histocompatibility molecules on enterocytes
نویسنده
چکیده
T cells with variable region Vä1ãä T cell receptors (TCRs) are distributed throughout the human intestinal epithelium and may function as sentinels that respond to self antigens. The expression of a major histocompatibility complex (MHC) class I-related molecule, MICA, matches this localization. MICA and the closely related MICB were recognized by intestinal epithelial T cells expressing diverse Vä1ãä TCRs. These interactions involved the á1á2 domains of MICA and MICB but were independent of antigen processing. With intestinal epithelial cell lines, the expression and recognition of MICA and MICB could be stress-induced. Thus, these molecules may broadly regulate protective responses by the Vä1ãä T cells in the epithelium of the intestinal tract. Gut 1998;43:166–167 166 group.bmj.com on June 26, 2017 Published by http://gut.bmj.com/ Downloaded from
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